Maximator® high pressure extruder

This continuous high pressure extruder (HPE) allows rapid and reproducible large-scale production of unilamellar liposomes by filter extrusion over polycarbonate membranes.


  • Schneider, T., Sachse, A., Rößling, G. and Brandl, M., Large-scale production of liposomes of defined size by a new continuous high pressure extrusion device. Drug Dev. Ind. Pharm. 20, 2787-2807 (1994).
  • Schneider, T., Sachse, A., Rößling, G. and Brandl, M., Generation of contrast-carrying liposomes of defined size with a new continuous high pressure extrusion method. Int. J. Pharm. 117, 1-12 (1995).
  • Muschick, P., Sachse, A., Leike, J., Wehrmann, D., Krause, W., Lipid dependent cardio-haemodynamic tolerability of liposomes in rats. J. Liposome Res. 5, 933-953 (1995)
  • Schneider, T., Sachse, A., Leike, J., Rößling, G., Schmidtgen, M., Drechsler, M., Brandl, M., Surface modification of continuously extruded contrast-carrying liposomes: effect on their physical properties. Int. J. Pharm. 132, 9-21 (1996).
  • Sachse, A., Leike, J.U., Schneider, T., Wagner, S.E., Rößling, G., Krause, W., Brandl, M., Biodistribution and computed tomography blood-pool imaging properties of polyethylene glycol-coated iopromide-carrying liposomes. Invest. Radiol. 32, 44-50 (1997).
  • Berger, N., Sachse, A., Bender, J., Schubert, R., Brandl, M., Liposome preparation by continuous and discontinuous extrusion, comparison of process parameters and liposome characteristics, Proc. 2nd World Meeting on Pharmaceutics, Biopharmaceutics, Pharmaceutical Technology, APGI/APV Paris, 655 (1998).
  • Reszka, R., Fichtner, I., Goan, S.-R., Rudolph, M., Winter, R., Encapsulation of the transition metal compounds carboplatin (CP) and lobaplatin (LP) in different types of liposomes and their physico-chemical, biochemical and biological characterization, in Bioinorganic Chemistry, Transition metals in biology and their coordination chemistry, (Trautwein, A. X., Ed.) Wiley-VCH, 145 (1998).
  • Sachse, A., Large-scale production of liposomes by continuous high pressure extrusion, in R.H. Müller, S. Benita and B. Böhm (eds.), Emulsions and nanosuspensions for the formulation of poorly soluble drugs, Medpharm Scientific Publ. 257-265 (1998).
  • Berger, N., Sachse, A., Bender, J., Schubert, R. and Brandl, M., Filter extrusion of liposomes using different devices: comparison of liposome size, encapsulation efficiency, and process characteristics, Int. J. Pharm. 223, 55-68 (2001) (Full text).